Endocrine Abstracts

Sirtuins are NAD+-dependent deacetylases that are implicated in mediating health benefits of calorie restriction and possibly exercise. We will report on novel roles of SIRT1-3 in diseases of aging and recent progress in using small molecules to activate SIRT1. Small molecule activators of SIRT1 (STACs), such as resveratrol and SRT1720, improve multiple health parameters in mice including protection from type II diabetes and hepatic steatosis. We developed an system...

Idiopathic intracranial hypertension (IIH) is a condition characterised by raised intracranial pressure (ICP) that primarily affects obese women of reproductive age. The aetiology is poorly understood but involves imbalance of cerebrospinal fluid (CSF) secretion and absorption. IIH patients share similar phenotypic characteristics to PCOS patients, a condition with a distinct androgen signature. We hypothesise that obesity and androgen excess maybe...

Idiopathic intracranial hypertension (IIH) is a condition characterised by raised intracranial pressure (ICP) that primarily affects obese women of reproductive age. The aetiology is poorly understood but involves imbalance of cerebrospinal fluid (CSF) secretion and absorption. IIH patients share similar phenotypic characteristics to PCOS patients, a condition with a distinct androgen signature. We hypothesise that obesity and androgen excess maybe...